MS patients positive to SARS-CoV-2 IgG/IgM were similar to patients negative to SARS-CoV-2 IgG/IgM in age (p = 0.830), sex (p = 0.988), EDSS (p = 0.642), DMTs (p = 0.486), comorbidities (p = 0.605), white blood cell count (p = 0.301), total lymphocyte count (p = 0.129), and lactic dehydrogenase (p = 0.452). Here, CD40LG is linked to myeloid sarcoma.