SCD and atherosclerosis: However, SCD1 inhibition is potentially responsible for adverse effects since the accumulation of SCD1 substrates result in inflammation, atherosclerosis, as well as liver and pancreatic dysfunction in pre-clinical models [104] (ii) The rationale for such a combination is also based on the fact that lipid targeted drugs and standard treatment address two complementary aspects of the metabolism and that neither drug alone can succeed in promoting cell death.