LPCAT2 and clear cell renal carcinoma: Indeed, the lysophosphatidylcholine acyltransferase 2 (LPCAT2), a lipid droplet-localized enzyme, promotes phosphatidylcholine synthesis and thereby attenuates drug-promoted ER stress, and finally blocks caspase activation and subsequent apoptosis [63] In clear-cell renal cell carcinoma, the constitutive activation of hypoxia-inducible factor-2α (HIF2α) promotes expression of the lipid droplet coat protein PLIN2 that contributes to the abundance of intracellular LDs.