DNER and small cell lung carcinoma: In order to determine whether BET inhibition impaired HR in SCLC cells, we applied the HR defect (HRD) gene signature, a selection of 230 genes that were differentially expressed between HR-proficient and HR-deficient cells, to previously published transcriptional profiling data of SCLC cell lines with or without JQ1 treatment [12,49,53].