In addition, Simoes et al. screened proteomics of CSF modulated by endosomal trafficking and newly found two molecules, Amyloid-like protein 1 (APLP1) and close homolog of L1 (CHL1), which had strong correlation to the levels of tau and phosphorylated tau in CSF samples from AD patients [120]. This evidence concerns the gene MAPT and Alzheimer disease.