Multivariate Cox regression analysis, including SSBP2 expression, age, sex, pT category, nodal status, histologic grade, lymphatic invasion, vascular invasion, perineural invasion, and tumor budding, revealed that age (p < 0.001), sex (p = 0.004), and vascular invasion (p < 0.001) were independent prognostic factors for a poor OS, while SSBP2 expression was not statistically significant (Table 3). The gene discussed is SSBP2; the disease is neoplasm.