CYP2C19 and fungal infectious disease: For example, in a study of 34 patients with an invasive fungal infection receiving voriconazole, it was shown that the effect of inflammation was modulated by the CYP2C19 genotype: the metabolic ratio of voriconazole and its metabolite was more decreased by inflammation in CYP2C19 ultrarapid metabolizers compared to CYP2C19 intermediate metabolizers [106].