Moreover, 5-uRCK and ellagic acid treatment significantly increased the expression of AMPK, p-AMPK, p-HMGCR, and INSIG-1 and decreased the expression of HMGCR and mSREBP-2 in a HCD-induced hypercholesterolemia rat model [24]. This evidence concerns the gene INSIG1 and Hypercholesterolemia.