Furthermore, 5-uRCK and ellagic acid treatment significantly increased the expression of AMP-activated protein kinase (AMPK), p-AMPK, p-HMGCR, and insulin-induced gene 1 (INSIG-1) in a dose-dependent manner and decreased the expression of HMGCR and mSREBP-2 in an HCD-induced hypercholesterolemia rat model [24]. Here, INSIG1 is linked to heavy chain disease.