Staining of sections with primary antibodies against CD4, CD8 and CD11c revealed that shIDO-ST treatment significantly increased infiltration of CD11c+ cells (p < 0.0001) in transformed lung tissue (as determined by IHC), while CD4+ and CD8+ cells remained unchanged and were largely confined to blood vessels with little infiltration into tumor tissue (Figure 2E). The gene discussed is ITGAX; the disease is neoplasm.