Tumor-infiltrating CD11b+F4/80+ cells remained significantly lower in shIDO-ST + IgG and shIDO-ST + ICB groups compared to shScr-ST groups indicating that this effect is due to shIDO-ST treatment alone, whereas ICB alone decreased CD11b+Ly6C+ in both shScr and shIDO-ST groups. The gene discussed is ITGAM; the disease is neoplasm.