S100A6 and melanoma: In contrast, S100A6 was strongly and diffusely positive in the junctional and dermal components of 100% (42/42) studied spitz nevi, positive in 56% melanocytic nevi (41/73), but only positive in 33% (35/105) of the dermal components of melanomas in the study done by Ribé and McNutt [100]; therefore, they proposed the idea of utilizing S100A6 for the differentiation of Spitz nevus from melanoma [100].