This study not only helped to identify Rpph1 as an AD-related ceRNA, but also to establish a whole lncRNA-miRNA-mRNA ceRNET including 4 lncRNAs (C030034L19Rik, Rpph1, A830012C17Rik and Gm15477), 5 miRNAs (miR-182-5p, miR-330-5p, miR-326-3p, miR-132-3p and miR-484), and 1082 mRNAs. Here, RPPH1 is linked to Alzheimer disease.