In addition, BACE1-AS is a ceRNA for miR-132-3p [26], which is downregulated in AD patients [125] and has been shown to provide neuroprotection in the disease via modulating different target mRNAs and affecting multiple pathways, including regulation of synaptic proteins, tau phosphorylation and amyloid aggregation [126,127,128,129,130]. Here, BACE1 is linked to Alzheimer disease.