Moreover, lncRNA GAS5 has been proposed as a ceRNA for miR-137 participating in the demyelination process [91] based on the following premises: (i) GAS5 is upregulated in MS patients while miR-137 is downregulated, (ii) GAS5 acts as a miR-137 molecular sponge in ischemic stroke [237] and (iii) GAS5 exacerbates demyelination and inhibits microglial M2 polarization in EAE mice and human primary cell culture [238]. Here, GAS5 is linked to ischemic stroke.