Second, Zhou et al. [45] showed that the lnc-ANRIL could regulate neuroinflammation in AD since its knockdown suppressed apoptosis and pro-inflammatory cytokines (TNF-α, Il-1β, Il-6 and Il-17) and promoted neurite outgrowth by targeting miR-125a in an AD cellular model. This evidence concerns the gene IL17A and Alzheimer disease.