PSEN1 and Alzheimer disease: It was the first AD-associated ceRNA network based on APP/PS1 mouse model and was found to be enriched in mRNAs related to AD-associated genes, various signaling pathways (MAPK, neurotrophin, insulin/IGF, ErbB), as well as in the regulation of actin cytoskeleton, adherent junction, axon guidance and long-term potentiation.