A review of the evidence shows that tumor necrosis factor (TNF-α), interferons (IFN-α/INF-β) and interleukins (IL-1α/IL-1β, IL-4–IL-6, IL-10, IL-13, IL-15–IL-20, IL-25, IL-31–IL-33) play a key role in the pathogenesis of allergic asthma [93]. This evidence concerns the gene TNF and allergic asthma.