TLR4 and asthma: It also exerts its anti-inflammatory activity using a toll like receptor (TLR-4) as a mediator to inhibit IL-1β-induced IL-6 secretion and downregulates IL-1 receptor-associated kinase 2 (IRAK-2) mRNA expression in H4 cells [100], a common adapter protein associated with susceptibility to early-onset asthma [101].