AR-A014418 represses TAK1 dimer formation with TAB1 (active form) in Panc-1 and MiaPaCa-2 cells, and this result suggests that the inhibitory effect on PDA cell proliferation induced by AR-A014418 is primarily due to the loss of GSK3α, rather than GSK3β, activity. The gene discussed is GSK3B; the disease is Patent ductus arteriosus.