Both GSK3 paralogs are upregulated in about 30% of prostate tumor cells [80]; however, GSK3α expression shows a stronger correlation in low Gleason score tumors and is mainly associated with the promotion of cell proliferation in response to androgen receptor (AR) transcriptional activity [80], while GSK3β is mainly expressed on high Gleason score tumors and promotes proliferation in AR-independent mechanisms [81]. This evidence concerns the gene AR and prostate neoplasm.