In short, these results suggest that mediators of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) stimulate IFN-γ production by Th1 cells and inhibit the production of Th2 cytokines and other proinflammatory markers such as leukotrienes, at least in asthma conditions. This evidence concerns the gene IFNG and asthma.