Our data suggest that the accessory components (RFC2, RFC3, RFC5, PCNA), polymerases (POLD1, POLD2, POLD3, POLE, POLE2, POLE4), and ligase LIG1, were downregulated during infection, for which the downregulation of RFC5, POLD1, POLD2, POLD3, POLE, and LIG1 was CagA-related. This evidence concerns the gene POLE4 and infection.