For example, the sustained elevation of pro-inflammatory mediators such as interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and transforming growth factor beta (TGFβ)-1 are likely to accelerate liver fibrosis and cause non-alcoholic steatohepatitis (NASH), a severe condition of NAFLD [14,15,16,17]. Here, TNF is linked to metabolic dysfunction-associated steatotic liver disease.