Experimental models of metabolic syndrome also show that, besides the regulation of MAPK, other transcriptional factors such as peroxisome proliferator-activated receptor gamma (PPARγ), CAAT/enhancer binding protein-α (C/EBPα) and sterol regulatory element binding protein (SREBP)-1c are increasingly studied for their role in adipogenesis and lipid-induced hepatic toxicity [31,34,35]. The gene discussed is PPARG; the disease is metabolic syndrome.