KLK3 and posterior cortical atrophy: The GPS (scale 0–100) combined with clinical parameters (GS, sPSA, Clinical Stage, PV, PSA Density) indicates the patients individualized risk on three clinical endpoints: (1) finding hg-PCa (GS ≥ 4 + 3) and/or high-stage PCa (≥pT3) upon RP, (2) metastasis within 10 years and (3) PCa death within 10 years.