To this end, we classified all cell lines of the Cancer Cell Line Encyclopedia (CCLE) [21], which includes gene expression data from 1076 cell lines, across 18 common cancer types, into highly invasive and less invasive on the basis of the expression levels of reliable markers for EMT and tumor progression such as N-cadherin, E-cadherin, Vimentin, ZEB1 and SNAI1 (Table S4) [22], and subsequently verified if neu.dev and/or behavioral genes are upregulated according to the invasive capacity of the tumor cells. This evidence concerns the gene ZEB1 and cancer.