Whereas, high tumoural PD‐1 associated with younger patients (p < 0.001), rectal tumours (p = 0.001), high TNM stage (p = 0.002), low Ki67 index (p < 0.001), high budding (p = 0.002), and unperforated tumours (p < 0.001). This evidence concerns the gene MKI67 and neoplasm.