CD8A and cancer: Furthermore, when assessing the local inflammatory infiltrate (see supplementary material, Table S3), CICSS 3 was significantly associated with high CD3+ T‐cells (p < 0.001) and CD8+ T‐cells (p < 0.001) in cancer cell nests, high stromal CD3+ T‐cells (p < 0.001) and CD8+ T‐cells (p < 0.001) and a total CD3+ or CD8+ high in both cancer cell nest and stroma score (both p < 0.001), as well as high stromal FoxP3+ T‐cells (p = 0.001), and a total FoxP3+ high in both cancer cell nest and stroma score (p = 0.010).