SEC61A1 and infection: Considerable progress has been made toward understanding the early stages of the infection, especially through elucidation of the multifaceted roles of mycolactone in host colonization: (i) an immunomodulatory activity, targeting the Sec61 channel, allowing immune escape [8–11], (ii) an analgesic effect, targeting AT2R receptors, and accounting for the absence of pain in patients with early lesions [12,13] and, (iii) cytotoxic activity, potentially linked to the Sec61-mycolactone interaction, responsible for tissue destruction [8,14,15].