Corroborating with therapeutic levels of dystrophin restoration, levels of serum creatine kinase (CK), which is usually elevated in DMD patients due to leaky muscle membrane (Kim et al, 2017), significantly declined in mdx mice treated with PMO‐M compared to PMO alone and untreated mdx controls (Fig 5A). The gene discussed is DMD; the disease is Duchenne muscular dystrophy.