Tumour‐secreted miR‐21 and miR‐29 also act as paracrine agonists of TLRs, which through interacting with either murine TLR7 or human TLR8 on immune cells transmit signals between tumour cells and the microenvironment, leading to regulation of tumour metastasis.57, 58. This evidence concerns the gene TLR8 and neoplasm.