For example Dppa2/4 are frequently up-regulated in human cancers including lung [56], ovarian [57], colon [58,59], colorectal [60] and gastric cancers [61], amongst others [62–66], likely due to the global demethylation that occurs in cancer cells, and are often associated with poor prognosis [57–61,65]. Here, DPPA2 is linked to cancer.