As a proof-of-concept study, HNF4α gene was efficiently posttranscriptional activated by the CRISPR/dCas9-VP64 mediated activation system in HSCs, while HNF4α is a transcriptional regulatory factor of hepatocytes differentiation and HNF4α could significantly attenuate hepatic fibrosis (Yue et al., 2010). This evidence concerns the gene HNF4A and Hepatic fibrosis.