Recently, SERPINA1 was reported to be a chaperone in amyloidoses, and it plays a role in amyloid aggregation, which may lead to the pathogenesis of amyloidotic diseases, for example amyotrophic lateral sclerosis (ALS), familial amyloid polyneuropathy (ATTR) and Alzheimer's disease.39, 40, 41. Here, SERPINA1 is linked to Alzheimer disease.