Moreover, CKD patients’ blood EVs from the same cohort induced osteocalcin expression in EPCs of healthy donors, VSMCs, and fibroblasts [91], pointing to a potential pathogenic role for EVs in vascular calcification what goes in line with the previously mentioned findings that showed decreased levels of fetuin-A, which is known to inhibit vascular calcification, in blood EVs from CKD patients [19]. The gene discussed is AHSG; the disease is chronic kidney disease.