Vice versa, in swine with pre-existing coronary artery disease that underwent hemorrhagic shock (HS) and resuscitation, treatment with sodium thiosulfate (Na2S2O3) during the first 24 h of resuscitation attenuated the impairment of lung mechanics and gas exchange, which coincided with higher lung tissue GR expression (as assessed by western blotting and immunohistochemistry, Fig. 5a, [78]). The gene discussed is NR3C1; the disease is coronary artery disorder.