Other biomarkers that can indicate the immune state in sepsis patients include apoptosis markers (Bim, Bid and Bac), caspases, leukocyte markers (HLA-DR, PD-1, FOXP3, CD127) and cytokines (IL-2, IL-6, IL-12, IL-17, IL-22, IL-33, TNF-α, IFN-γ, IL-10 and TGF-β). This evidence concerns the gene TNF and Sepsis.