SERPINE1 and fatty liver disease: Moreover, we have shown that attenuating ER stress with 4‐PBA does not reduce the severity of MCD diet‐induced hepatic steatosis, liver injury, or lipid peroxidation in mice; yet, attenuating ER stress in this model, did suppress hepatic Pai‐1 induction indicating that induction of Pai‐1 in this murine model of NASH is not purely a consequence of ER stress‐induced liver injury or oxidative stress.