BDNF and Cognitive impairment: Additionally, Shen et al. showed that the neuroprotective effect of RSV on chronic unpredictable mild stress -induced cognitive impairment may rely on activating SIRT1/miR-134 pathway and then upregulating its downstream element-binding protein (CREB) and brain derived neurotrophic factor (BDNF) expression in hippocampus (Shen et al., 2018).