In the present study, IL10, IL-17, Th1, and Th17 were not measured, whereas the results suggest that the worst clinical manifestations seen in BD patients with LTBI are not mediated by the leukocyte levels, C-reactive protein levels, or the levels of immunoglobulins G, A, M, and E. Since the LTBI group showed higher frequency, number, and scope of oral ulcers, higher incidence of genital ulcers, and more frequent eye involvement than the non-LTBI group, immune factors other than the ones available in the present study might be responsible for those worst manifestations. The gene discussed is CRP; the disease is Oral ulcer.