ZG16B was first discovered to act as a growth factor overexpressed in pancreatic cancer, which enhances tumor proliferation and helps escape from innate immune system by intriguing TLR-mediated ERK signaling, inhibiting TLR-mediated NF-kappa B signaling and keeping β-catenin stable through phosphorylation [21,24,25]. Here, ZG16B is linked to neoplasm.