S100PBP [68], PRR4 [69], ANKEF1 [39,70], EPCAM [71], SPDEF [72], KRT8, KRT19 [73], KIAA1324 [74,75], CXCR4 [76,77], AGR2 [78,79,80], SCNN1A [81], AP1M2 [82], CLDN4 [83], and ERBB3 [84,85] have been reported to have correlations with breast cancer or have been identified as biomarkers for diagnosis, metastasis, and prognosis of breast cancer and even as therapeutic targets. The gene discussed is SPDEF; the disease is breast carcinoma.