GDNs dampen inflammation and epithelial erosion in the DSS-induced ulcerative colitis in mouse; reduce anti-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and induce anti-inflammatory and pro-healing cytokines (IL-10, IL-22); accelerate wound healing in Caco2-BBE monolayers. The gene discussed is IL10; the disease is ulcerative colitis.