Although PI3K/Akt/mTOR signaling has been corroborated to increase chemotolerance of cancer cells, such as PC and anaplastic thyroid carcinoma [25], documentations that elucidated the collaborative role of SRPX2 and PI3K/Akt/mTOR signaling in regulating PC chemosensitivity were scarce. This evidence concerns the gene SRPX2 and pachyonychia congenita.