SRPX2 and pachyonychia congenita: The univariate Cox regression analyses also indicated that the six items were associated with 3 year survival of PC patients, while multivariate analysis presented that TNM stage, high serum SRPX2 level and SRPX2 level change before and after chemotherapy were independent involvers in forecasting unfavorable PC prognosis (all P < 0.05) (Table 1).