For example, lncRNA LOC101928316 facilitated the development of GC by modulating the PI3K/AKT/mTOR signaling pathway [12]; MALAT1/miR-183/SIRT1 axis contributed to the regulation of GC via PI3K/AKT/mTOR pathway [13] and lncRNA XLOC_006753 could induce cell proliferation, cell cycle, and metastasis but inhibit apoptosis in multidrug-resistant GC cells through promoting the PI3K/AKT/mTOR pathway [33]. Here, SIRT1 is linked to gastric cancer.