Compared with patients who had milder COVID-19, those who developed severe COVID-19 after admission had significantly lower lymphocyte counts, platelet counts, estimated glomerular filtration rates (eGFRs), CD4+ T-cell counts, CD8+ T-cell counts, and PaO2/FiO2 ratios, and significantly higher C-reactive protein levels, lactate dehydrogenase levels, aspartate transaminase levels, and beta 2-microglobulin levels (Table 3). The gene discussed is CD4; the disease is COVID-19.