Besides, pro-apoptotic protein Bax or Bak forms a large pore with VDAC, allowing the release of cytochrome C. As was reported before, VDAC1 is involved in the process of mitochondria-mediated apoptosis by mediating the release of pro-apoptotic proteins and interacting with anti-apoptotic proteins in tumor cells as well as in other cells. The gene discussed is VDAC1; the disease is neoplasm.