Among them, PTPRC, CTLA4, SELL, ITGB2, TLR4, CXCR4, TLR8, PLEK, CD69, and IKZF1 with high degrees are considered as hub-genes, which suggests they may play important roles in the development of metastasis of melanoma (Figure 4). Here, ITGB2 is linked to melanoma.