Various proinflammatory cytokines have been shown to stimulate the activity of proteolytic enzymes on the aortic wall [5], including tumor necrosis factor-α (TNF-α), osteopontin (OPN) and osteoprotegerin (OPG), which appears to be a very promising marker in the diagnosis and as the target in the therapy of AAA. This evidence concerns the gene TNFRSF11B and triple-A syndrome.