The results showed that high SIRT6 expression was related to a favorable tumor node metastasis (TNM) stage (OR = 0.44, 95% CI = 0.28–0.70, P = 0.001; I2 = 23.7%, P = 0.263, fixed-effects model) (Figure 3 and Table 2). Here, SIRT6 is linked to neoplasm.