ADRB2 and obesity disorder: Numerous genetic association studies have suggested that these variants may modulate the risk of developing heart failure, asthma and airway hyper-responsiveness, protection from traumatic or septic shock, obesity, and cancer, where β2AR plays a central role.10, 11, 12, 13, 14 Nevertheless, data often lead to conflicting mechanistic explanations, likely relating to the complex and heterogenic nature of the ADRB2 locus.15