Moreover, PCa cells that overexpress CD117 and ATP-binding cassette super-family G member 2, ABCG2 (CD117+/ABCG2+), an ubiquitous ATP-binding cassette transmembrane protein that is highly expressed in multi-drug resistant tumor cells, are highly prolific and exhibit multidrug resistance, being able to self-renew and differentiate, as well as to generate tumors in vivo similar to the ones from which they were first isolated (Liu et al., 2010). Here, ABCG2 is linked to neoplasm.