Whilst adiponectin, an adipokine produced primarily by adipose tissue, is known to hold a number of important metabolic functions (e.g., insulin-sensitizer and anti-inflammatory), these responses become dysregulated with obesity, making skeletal muscle particularly susceptible to metabolic impairments and increased risk of morbidity (64, 65). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.