NPR3 and posterior cortical atrophy: In a preclinical study, Pressly et al. (2013) reported that the presence of NPR-C in PCa tissues, confirmed by immunohistochemistry staining, has been exploited to establish a new nanoagent for PET imaging by synthesizing an amphiphilic comb-like nanoparticle containing C-atrial natriuretic factor (CANF) with copper-64 (64Cu) radiolabeling for NPR-C targeting (Figure 7).