One classic example, from a virus associated cancer is the HPV E7 oncoprotein, which binds to interferon regulatory factor 1 (IRF1) in the IFN type I (IFN-I) signaling pathway, and recruits histone deacetylase (HDAC) to the promoter sequences responsive to IRF1, repressing genes that otherwise would be transcribed in response to the virus (22). This evidence concerns the gene IRF1 and cancer.