Compared to GB/PC-KO, GB/PC-WT mice displayed increased IL-2 levels, tumor proliferation, FoxP3+PD-1+CTLA-4+ TILs, higher Tgfβ, and Il10 mRNA expression levels, and a CD4+/CD8+ ratio of 4:1. The gene discussed is PDCD1; the disease is neoplasm.