VEGFA and neoplasm: This is achieved through a process called angiogenesis, where hypoxic conditions stimulate vascular endothelial growth factor (VEGF) secretion and start a multidimensional process regulated by cancer cells in concert with various immune cells, fibroblasts, and other TME cells that results in the growth of new blood vessels, which further supports tumor survival and induction of metastasis (104, 105).