STAT3 and breast carcinoma: Likewise, Zerumbone, a monocyclic natural anti-inflammatory and antioxidant agent, suppresses EGF-induced CD44 expression through STAT3 pathway inhibition in breast cancer cell lines, while combined STAT3 and NF-kB inhibition with curcumin and epigallocatechin gallate decreases the CD44+ breast CSC population (88, 239).