STAT3 and lung carcinoma: Next, across various cancer models, full-length CD44 has been shown to translocate to the nucleus, physically bind to nuclear STAT3 and p300 acetyltransferase, and promote STAT3 acetylation at lysine 685, which elicits cell proliferation and stem cell-like phenotype in colon, gastric, and lung cancer cell lines (90, 93).