Immunohistochemical results showed negative expression of mTOR and NOX4 in the bone tissue of group A and positive expression in the bone tissue of group B. These results further confirmed that upregulation of miR-100-5p expression could significantly affected the expression of mTOR and that miR-100-5p played a role in the occurrence and development of PCa through targeted regulation of mTOR. Here, MTOR is linked to posterior cortical atrophy.