Recently, a retrospective study of 1,027 patients with stage I–III colon cancer conducted by the Memorial Sloan Kettering Cancer Center showed that patients with elevated preoperative CEA and normalized after resection, had recurrence-free survival similar to that of patients with normal preoperative CEA, which indicated that elevated postoperative CEA was a more important indicator for prognosis in colon cancer than preoperative CEA (6). Here, CEACAM5 is linked to malignant colon neoplasm.