T (tumor) stage (P < 0.0001), tumor stage (P = 0.014) and serum positive CEA (P = 0.003)/NSE (P = 0.04) at baseline were all significantly associated with shorter OS (Figure 2); furthermore, different chemotherapy regimes also appeared a significant trend (P = 0.059) (Supplement Figure 1). Here, CEACAM5 is linked to neoplasm.