S100A9 and Sepsis: Because exosomes derived from late sepsis Gr1+CD11b+ MDSCs blocked S100A9 secretion and switched naive Gr1+CD11b+ cells to MDSCs (Figures 1 and 2); and because most immune-related lncRNAs can bind to and affect protein modifications and transport [21,22,24], we hypothesized that lncRNAs in exosomes contribute to S100A9 nuclear localization in Gr1+CD11b+ cells after early sepsis response.