In our study, we observed that blunting the expression of miR-107 using antagomiR-107 in the AD mice failed to activate autophagy, whereas IVX treatment rescued the autophagic mechanism – indicated by increased expression of LC3-II, Atg7 and beclin-1 – against STZ-induced autophagic failure in the hippocampus of AD mice. This evidence concerns the gene ATG7 and Alzheimer disease.