In the current study, IVX administration in the AD mice depicted that protein expressions of p-PI3K, p-Akt and p-mTOR were mitigated in the hippocampal tissues against activated PI3K/Akt/mTOR signalling in the antagomiR-107/STZ co-treated and STZ-induced AD mice. This evidence concerns the gene AKT1 and Alzheimer disease.